Integrity Testing

Automatic filter integrity test machine photo

Integrity testing of pleated membrane filter cartridges is done to test the efficiency of the membrane seal property to detect defects if any of the membrane & to judge if the pore size of the membrane is consistent with the specification.

The common non-destructive test carried out on sterilizing grade membrane filters (less than 1 micron) are bubble point test & diffusion test. Sterilizing grade membrane filters are used to reduce/remove the microbial content from the process stream. They must be tested before & after filtration to ensure that:

  1. The filter was installed correctly
  2. The filter used was of correct pore size
  3. The filter & its sealing were free of defects

Integrity testing is thus mandatory to ensure the product sterility as well as regulatory compliance.